维甲酸,维甲酸胶囊tretinoin (Vesanoid Capsule 10mg)

药店国别:

产地国家:香港

处方药:

所属类别: 10毫克/胶囊 100胶囊/瓶

包装规格: 10毫克/胶囊 100胶囊/瓶

计价单位:

生产厂家中文参考译名:

生产厂家英文名:Roche Hong Kong Limited

原产地英文商品名:Vesanoid 10MG/Capsule 100Capsule/botte

原产地英文药品名:Tretinoin

中文参考商品译名:维A酸 10毫克/胶囊 100胶囊/瓶

中文参考药品译名:维甲酸

曾用名:

简介

部份中文维A酸资料(仅供参考)

英文品名: Tretinoin

别  名: Airol, Arotinoid, Retinoic acid, Vesanoid, Vitamin A acid

品种类别: 抗肿瘤药>维生素A衍生物

[药物毒理]

本品是一种肿瘤细胞诱导分化剂,不仅能维持正常上皮细胞的分化作用,而且可使白血病细胞分化为具有正常表现型功能的血细胞,体外可抑制癌细胞增殖。

[药代动力学]

口服吸收后,可通过肝脏与蛋白结合,被运转至全身,经胆汁排出,口服1mg/kg后,血药峰浓度可达0.3~0.5μg/ml。[适应症]1995年上市(Roche,美国)。当与细胞生长抑制剂联用时,维A酸诱导分化和显示较强的抗肿瘤活性,用于急性早幼粒细胞白血病。外用还可能有治疗光损伤皮肤和皮肤癌的潜力。

[规格]20mg

[用法用量]每日40~80mg(最高不超过0.12g),分2~4次口服,疗程4~8周。

[不良反应]皮肤粘膜干燥、消化道反应、头晕及关节痛,停药后消失。

[注意事项]

1.服用本品后需监测肝功能、血脂。

2.不能与四环素及维生素A同时使用。

[孕妇及哺乳期妇女用药]孕妇禁用。

[贮藏]避光,密封,在阴凉干燥处保存

英文版说明

Generic Name for VESANOIDTretinoin 10mg; soft gelatin caps; contain parabens.Legal Classification:RxPharmacological Class for VESANOIDRetinoid.Manufacturer of VESANOIDRoche LaboratoriesIndications for VESANOIDInduction of remission in patients with acute promyelocytic leukemia(APL), French-American-British (FAB) classification M3 (including the M3 variant), characterized by the presence of the t(15;17) translocation and/or the presence of the PML/RARα gene who arerefractory to, or who have relapsed from, anthracycline chemotherapy, or for whom anthracycline-based chemotherapy is contraindicated.Adult dose for VESANOIDUse only for induction of remission. 45mg/m2 per day in two divided doses until complete remission is documented. Discontinue 30 days after complete remission or after 90 days of treatment, whichever occurs first.Children's dosing for VESANOIDSee literature.Warnings/Precautions for VESANOIDConfirm APL diagnosis. Monitor for Retinoic Acid-APL (RA-APL) syndrome, leukocytosis, pseudotumor cerebri, or respiratory compromise. Consider temporarily interrupting therapy if moderate to severe RA-APL syndrome develops. Monitor blood counts, coagulation profile, lipids, liver function; consider temporary withdrawal if tests >5XULN. Pregnancy (Cat.D); obtain negative pregnancy test 1 week before starting treatment, counsel patient about need to use 2 effective methods of contraception during, and 1 month after therapy. Nursing mothers: not recommended.Interactions for VESANOIDDo not administer with Vitamin A. May be potentiated or antagonized by CYP450 enzyme inducers or inhibitors.Caution with anti-fibrinolytic agents; and other agents known to cause pseudotumor cerebri/intracranial hypertension.Adverse Reactions for VESANOIDHeadache, fever, skin/mucous membrane dryness, bone pain, GI upset, rash, mucositis, pruritus, increased sweating, visual disturbances, alopecia; RA-APL syndrome, leukocytosis, pseudotumor cerebri, hypercholesterolemia/hypertriglyceridemia, others.How is VESANOID supplied?Caps—100Related Disease:Leukemia, acute promyelocytic

 

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