维甲酸,维甲酸胶囊 ベサノイドカプセル(VESANOID Capsule 10mg)

药店国别:

产地国家:日本

处方药:

所属类别: 10毫克/胶囊 100胶囊/瓶

包装规格: 10毫克/胶囊 100胶囊/瓶

计价单位:

生产厂家中文参考译名:

生产厂家英文名:Fujifilm

原产地英文商品名:VESANOID(ベサノイドカプセル)10mg/Capsule 100Capsule/bottle

原产地英文药品名:Tretinoin

中文参考商品译名:维A酸(ベサノイドカプセル) 10毫克/胶囊 100胶囊/瓶

中文参考药品译名:维甲酸

曾用名:

简介

部份中文维A酸资料(仅供参考)

英文品名: Tretinoin

别  名: Airol, Arotinoid, Retinoic acid, Vesanoid, Vitamin A acid

品种类别: 抗肿瘤药>维生素A衍生物

[药物毒理]

本品是一种肿瘤细胞诱导分化剂,不仅能维持正常上皮细胞的分化作用,而且可使白血病细胞分化为具有正常表现型功能的血细胞,体外可抑制癌细胞增殖。

[药代动力学]

口服吸收后,可通过肝脏与蛋白结合,被运转至全身,经胆汁排出,口服1mg/kg后,血药峰浓度可达0.3~0.5μg/ml。

[适应症]1995年上市(Roche,美国)。

当与细胞生长抑制剂联用时,维A酸诱导分化和显示较强的抗肿瘤活性,用于急性早幼粒细胞白血病。外用还可能有治疗光损伤皮肤和皮肤癌的潜力。

[规格]20mg

[用法用量]每日40~80mg(最高不超过0.12g),分2~4次口服,疗程4~8周。

[不良反应]皮肤粘膜干燥、消化道反应、头晕及关节痛,停药后消失。

[注意事项]

1.服用本品后需监测肝功能、血脂。

2.不能与四环素及维生素A同时使用。

[孕妇及哺乳期妇女用药]孕妇禁用。

[贮藏]避光,密封,在阴凉干燥处保存包装

英文版说明

japic_code=00053020tretinoinPronunciation: TRET i noinBrand: VesanoidWhat is tretinoin?Tretinoin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.Tretinoin is used to treat acute promyelocytic leukemia (a type of blood cancer).Tretinoin may also be used for other purposes not listed in this medication guide.What is the most important information I should know about tretinoin?Do not use vitamin A supplements or multivitamins that contain vitamin A while you are taking tretinoin.Do not use this medication without your doctor's consent if you are pregnant. It could cause harm to the unborn baby.Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.Tretinoin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.What should I discuss with my healthcare provider before taking tretinoin?Before using tretinoin, tell your doctor if you have high cholesterol, or if you have ever had a reaction to another retinoid (such as Accutane, Retin-A, Renova).If you have any of these conditions, you may not be able to use tretinoin, or you may need a dosage adjustment or special tests during treatment.FDA pregnancy category D. This medication can cause birth defects, miscarriage, premature birth, or death of a baby.Do not use tretinoin if you are pregnant. Tell your doctor right away if you miss a period or become pregnant during treatment.Use an effective form of birth control while you are using this medication and for at least 1 month after your treatment ends.You may need to have a pregnancy test every month during your treatment. You must use effective birth control while you are taking tretinoin unless you have had a hysterectomy and no longer have a uterus.Use birth control even if you have been infertile (unable to have children) in the past, or if you have gone through menopause.It is not known whether tretinoin passes into breast milk or if it could harm a nursing baby.Do not take tretinoin without tellingyour doctor if you are breast-feeding a baby.How should I use tretinoin?Take this medication exactly as it was prescribed for you.Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.Take each dose with a full glass of water.You may need to continue taking tretinoin for up to 90 days.Follow your doctor's instructions.Store tretinoin at room temperature away from moisture, heat, and light.What happens if I miss a dose?Contact your doctor if you miss a dose of tretinoin.What happens if I overdose?Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include headache, dizziness, weakness, facial flushing, stomach pain, or dry, cracked lips.What should I avoid while using tretinoin?Do not use vitamin A supplements or multivitamins that contain vitamin A while you are taking tretinoin.Tretinoin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.What are the possible side effects of tretinoin?Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have any of these serious side effects:· fever, breathing problems, weight gain, swelling of your hands or feet;· sudden and severe pain behind your eyes, with nausea, vomiting, and vision problems;· black, bloody, or tarry stools; or· vomit that looks like blood or coffee grounds.Less serious side effects may include:· feeling tired or weak;· headache;· fever;· dry skin, mouth, or nose;· bone pain;· nausea and vomiting;· rash or itching;· white patches or sores inside your mouth or on your lips;· increased sweating;· vision problems; or· hair loss or skin changes.This is not a complete list of side effects and others may occur.Tell your doctor about any unusual or bothersome side effect.What other drugs will affect tretinoin?Before taking tretinoin, tell your doctor if you are using any of the following drugs:· cimetidine (Tagamet);· cyclosporine (Neoral, Sandimmune, Gengraf);· troleandomycin (Tao);· rifampin (Rifadin, Rimactane, Rifater);· phenobarbital (Luminal);· fluoxetine (Prozac), fluvoxamine (Luvox);· steroids (prednisone and others);· itraconazole (Sporanox), ketoconazole (Nizoral);· clarithromycin (Biaxin), erythromycin (Erythrocin, Ery-Tab, E.E.S.);· a tetracycline antibiotic such as minocycline (Dynocin, minocin, Vectrin), doxycycline (Doryx, Vibramycin), demeclocycline (Declomycin);· amiodarone (Cordarone), mibefradil (Posicor), diltiazem(Tiazac, Cardizem), verapamil (Covera, Calan); or· HIV medicines such as indinavir (Crixivan), saquinavir(Invirase), ritonavir (Norvir), saquinavir (Invirase), or nelfinavir(Viracept).This list is not complete and there may be other drugs that can interact with tretinoin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.Do not start using a new medication without telling your doctor.Where can I get more information?Your pharmacist can provide more information about tretinoin—————————————————————附件:20119418263925.PDF

 

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