普来纳西注射混悬液(Plenaxis injectable suspension 100mg)



所属类别 100毫克/瓶 1瓶/盒

包装规格 100毫克/瓶 1瓶/盒



原产地英文商品名Plenaxis injection 100mg/vials 1vials/bottle, cold chain product (storage at 2-8 degrees) extra charge for packaging


中文参考商品译名普来纳西注射混悬液  100毫克/瓶 1瓶/盒 冷链产品(储存在2-8度),需要额外的包装费用




英文药名: Plenaxis(abarelix for injectable suspension)

中文药名: 普来纳西(阿巴瑞克注射混悬液)


药品介绍:2003年11月25日,Praecis制药公司宣布,FDA已批准其开发的Plenaxis(abarelix注射用混悬液)上市,这是目前得到批准的第一种可存储的促性腺激素释放激素拮抗剂配方, Plenaxis是第一个促性腺素释放激素(GnRH)拮抗剂,为长效混悬剂配方。






(Gonadotropin-releasing hormone antagonist) is a synthetic peptide that competes with the neurohormone GnRH for its receptor, thus decreasing or blocking GnRH action. As a result endogenous pituitary output of FSH and LH is shut down.GnRH antagonists are also derivatives of the natural GnRH decapeptide with multiple amino acid substitutions. These substitutions modify the agent so that it blocks the receptor and decreases FSH and LH secretions within hours. In contrast to GnRH agonists, antagonists have no flare effect, thus their therapeutic effect is immediately apparent. However, their action is short-lived and daily injections are necessary to maintain their effect. Typically endogenous FSH and LH activity returns about 40 hours after cessation of GnRH antagonist administration, although with a higher dose the return to normal pituitary function will be postponed for longer. Unlike the GnRH agonists, long acting or depot forms of the agent are not currently available, thus GnRH antagonists are not used in the long term therapy of patients with cancer where hormone levels need to be kept low for a long time. As of 2006, Histrelin (as Supprelin-LA) is awaiting approval for use as a 12-month depot injection.The main application of GnRH antagonists is currently short term use in the prevention of endogenous ovulation in patients who undergo exogenous stimulation with FSH in the preparation for IVF. Typically they are administered in the mid- to late follicular phase in stimulated cycles prior to the administration of hCG. Because they decrease luteal competence, patients are usually given some form of luteal support after egg retrieva l.GnRH antagonists for long term use are under investigation (i.e. abarelix), their advantage over GnRH agonist would be that they lack the initial flare stimulation and induce quickly a hypogonadal situation.

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