原产地英文商品名：NINLARO 4MG CAP 1X3UD DS
中文参考商品译名：NINLARO胶囊 4毫克/粒 1板X3粒
剂量和给药方法：⑴ 推荐起始剂量4mg口服在28-天疗程的第1，8，和15天。⑵ 剂量应被服用食物前至少一小时或后至少2小时。
特殊人群中使用：⑴ 肝受损：在有中度或严重肝受损患者减低NINLARO开始剂量至3mg。⑵ 肾受损：有严重肾受损或肾病终末期需要透析患者减低NINLARO开始剂量至3 mg。⑶ 哺乳：终止哺乳。
NINLARO(ixazomib) is the first and only oral medication of its kind, a proteasome inhibitor, that you can take at home. A study showed that adding NINLARO to REVLIMID(lenalidomide) and dexamethasone improved median progression-free survival (PFS) by nearly 6 months (20.6 months with the NINLARO regimen and 14.7 months with the placebo regimen).INDICATION AND IMPORTANT SAFETY INFORMATION FOR NINLARO(ixazomib)Uses of NINLARONINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID(lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.It is not known if NINLARO is safe and effective in children.NINLARO may cause serious side effects, including:Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs.Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your arms, hands, legs, ankles, or feet, or if you gain weight from swelling.Skin Reactions. Tell your healthcare provider if you get a new or worsening rash.Liver problems. Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper-stomach area.Other common side effects have occurred. Tell your healthcare provider if you get new or worsening back pain, lowered white blood cells (neutropenia) that may increase the risk of infection, or vision conditions such as blurred vision, dry eye, or pink eye (conjunctivitis).These are not all the possible side effects of NINLARO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if:You have liver problems or kidney problems or are on dialysis.You or your partner are pregnant or plan to become pregnant. NINLARO can harm your unborn baby. Avoid becoming pregnant during treatment with NINLARO. You and your partner should use effective birth control during treatment and for 90 days after the final dose of NINLARO. If using hormonal contraceptives (for example, the pill), an additional barrier method of contraception (for example, diaphragm or condom) must be used.You are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with NINLARO and for 90 days after your final dose of NINLARO.
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