卡铂注射用输液carboplatin(paraplatin 150mg/15ml Vial)

产地国家:意大利

处方药:是

所属类别:150毫克/15毫升/瓶

包装规格:150毫克/15毫升/瓶

计价单位:瓶

生产厂家英文名:BRISTOL-MYERS SQUIBB Srl

原产地英文商品名:paraplatin solution Injectable 150mg/15ml/Vial

原产地英文药品名:carboplatin

中文参考商品译名:伯尔定注射用输液 150毫克/15毫升/瓶

中文参考药品译名:卡铂

简介:

部分中文卡铂处方资料(仅供参考)

【英文药名】PARAPLATIN(carboplatin)

【中文药名】卡铂注射剂

【生产厂家】BRISTOL-MYERS SQUIBB

【药品介绍】卡铂为第二代铂类抗肿瘤药,具细胞周期非特异性,作用与烷化剂类似。卡铂细胞杀伤作用可能是由于其与DNA产生链间和链内交联,导致DNA损伤,以至DNA的复制和转录受损。单用时,卡铂的剂量4倍于顺铂,且细胞中出现DNA交联作用较顺铂缓慢。

【适应症】用于晚期卵巢癌、小细胞和非小细胞肺癌、头颈部鳞癌、晚期膀胱癌(需与其他药物合用);对子宫颈癌有显著疗效

【用法用量】本品仅供静脉使用。根据Calvert公式(Journal of Clinical Oncology,1989,1748~1756)以AUC确定个体化的伯尔定用药剂量,可以避免剂量不足或过量。但根据公式得到的伯尔定剂量是用药的总剂量,而不是mg/m2的剂量。

英文版说明书

Brand name : PARAPLATIN INJECTION 450mg Active ingredient: Carboplatin Dosage form: injection Print on wrapping:Effects of this medicineThis medicine inhibits growth of cancer cells at a cell division level and destroy the cells.It is usually used to treat head and neck cancer, small cell lung cancer, testicular tumor, ovarian tumor, uterine cervical cancer, malignant lymphoma, non-small cell lung cancer, breast cancer and pediatric malignant solid tumor (neuroblastoma, retinoblastoma, hepatoblastoma, central nervous system germ cell tumor, recurrent/refractory Ewing’s sarcoma family of tumor, nephroblastoma).Before using this medicine, be sure to tell your doctor and pharmacist•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.If you have impaired renal/hepatic function, low level of white blood cells or other blood components, fever or chicken pox.•If you are pregnant, possibly pregnant or breastfeeding.•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)Dosing schedule (How to take this medicine)•Your dosing schedule prescribed by your doctor is <>•In general, repeat the cycle of administering once a day or 2 days with a drug cessation period of 3 to 4 weeks.•It may be administered over a long period according to your response to the treatment.•In order to prevent nausea, medicines for nausea may be used in advance.Precautions while taking this medicine• Possible adverse reactions to this medicineThe most commonly reported adverse reactions include nausea/vomiting, loss of appetite, hives, loss of hair, general malaise, fever, diarrhea, stomatitis, stomachache, constipation, rash, urine with blood, protein urea, edema, chill, dehydration, weight loss, respiratory distress, peripheral neuropathy and headache. If any of these symptoms occur, consult with your doctor or pharmacist.The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.•fever, chill, cough, nasal discharge, dizziness, bleeding tendency, continuous bleeding, bruise, dullness, easy fatigability, shortness of breath, sore throat [myelosuppression such as pancytopenic]•lips/nails turning bluish-purple, breathing difficulty/chest tightness, suddenly feeling unwell, dizziness [shock, anaphylaxy]•fever, cough, breathing difficulty/chest tightness [interstitial pulmonary disease]•inability to pass urine, urine with blood [acute renal failure]•jaundice [hepatic failure, hepatic function disorder, jaundice]•severe stomachache, hematoma [gastrointestinal necrosis, gastrointestinal perforation, gastrointestinal bleeding, gastrointestinal ulceration]•severe stomachache, diarrhea [hemorrhagic enteritis, pseudomembranous colitis]•loss of appetite, nausea/vomiting, severe constipation, stomachache, abdominal distention, retention of bowel contents [paralytic ileus]•decreased consciousness, numbness of limbs, breathing difficulty [cerebral infraction, lung infraction]•numbness of limbs, breathing difficulty [thrombosis/embolism]•palpitation, shortness of breath, chest pain, breathing difficulty [myocardial infarction, congestive heart failure]•bleeding tendency, continuous bleeding, failure of urinating, yellowness in the skin or whites of the eyes, dizziness, purple spots in the skin [hemolytic-uremic syndrome]•sudden respiratory distress [acute respiratory distress syndrome]•bleeding tendency, continuous bleeding [disseminated intravascular coagulation]•severe upper abdominal pain [acute pancreatitis]•hearing loss [hearing impairment]•unstableness while walking, speech disorder, memory loss, slow movement [leukoencephalopathy (reversible posterior leukoencephalopathy)]The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.Bristol-Myers SquibbInjectionRevised: 8/2014The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

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