甲磺酸伊马替尼胶囊(GLIVEC 100mg capsules)



所属类别: 100毫克/胶囊 60胶囊/盒

包装规格: 100毫克/胶囊 60胶囊/盒



原产地英文商品名:GLIVEC 100mg/cap 60caps/box


中文参考商品译名:格列卫 100毫克/胶囊 60胶囊/盒




药品名称:imatinib mesylate

商 品 名:GLIVEC











Based on the striking results of phase II clinical trials, Glivec was filed for registration and received approval from the European Union (EU) (May 31, 2002), the Food and Drug Administration (FDA) in the United States (February 1, 2002), and other countries for the treatment of adult patients with c-Kit (CD117)–positive unresectable and/or metastatic malignant GISTs. On December 19th, 2008, Glivec was also approved for adjuvant treatment for patients in the United States. Glivec is approved for GIST in many different countries, although it is probably approved in fewer countries for adjuvant use.Glivec is known by several different names:•Gleevec in the U.S.•Glivec outside the U.S.•Imatinib Mesylate (the generic name).•STI571 when it was in clinical trials (STI stands for Signal Transduction Inhibitor).Glivec is a pill that is taken either once or twice daily, depending on the dose.Glivec is different from traditional chemotherapy in that it is very selective. Traditional chemotherapy kills all cells that are dividing quickly. This is what causes so many of the side effects of traditional chemotherapy. In addition to the cancer cells, this type of chemotherapy also kills many of the body’s normal cells. Glivec is much more selective and as a result has fewer side effects. It was designed to block the activity of a mutant type of enzyme (an enzyme is a specific type of protein) that causes Chronic Myeloid Leukemia (CML). This enzyme is called Bcr/Abl. In addition to blocking Bcr/Abl, Gleevec also blocks several other enzymes. These are:•KIT•Platelet Derived Growth Factor Receptors (PDGFR-alpha and PDGFR-beta)•Various forms of the Abl enzymesThe KIT receptor belongs to a class of receptors called the tyrosine kinase family. It is estimated that the human genome will reveal more than 400 tyrosine kinases. Because Glivec selectively blocks only a few of these tyrosine kinases, it is both effective and has fewer side effects than traditional chemotherapy.For normal signal transduction to occur in the KIT receptor, a chemical called ATP (adenosine triphosphate) must bind to a site in the kinase domain of the receptor. Glivec prevents signal transduction of KIT by binding to this ATP binding site. This prevents the transfer of phosphate groups from ATP and blocks signal transduction in normal and mutated forms of KIT.Glivec is introduced in a tablet form•Glivec 400mg and 100mg tablets have replaced the 100mg capsules to make therapy more convenient for all patients.•It is important for you to understand that you will receive exactly the same medicine in the new Glivec tablets that you have come to know.

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