原产地英文商品名：AMSIDINE INJECTION 75mg/1.5ml/bottle
[外 文 名]
AMSA，M-AMSA，AMS，CI-880，NSC-156303，SN-11841。[化 学 名] N-[4-(9-吖啶氨基)甲基苯基]甲磺酰胺。
[分 子 式]
(4) 本品与Ara-C、Vp-16合用能增台疗效。[制剂规格] 注射剂：75mg/1.5ml,附稀释剂。
Amsacrine (Amsidine)Amsacrine is a chemotherapy| drug that is usually given in combination with other chemotherapy drugs to treat types of adult and childhood leukaemia|.What amsacrine looks likeAmsacrine is an orange/red coloured fluid.How it is givenAmsacrine is given by a drip (infusion) in one of the following ways:through a fine tube (cannula) placed into the vein, usually in the back of the hand through a fine plastic tube inserted under the skin into a vein near the collarbone (central line) into a fine tube inserted into a vein in the crook of your arm (PICC line ).The infusion usually takes between 60 and 90 minutes.Chemotherapy is usually given as a course of several sessions (or cycles) of treatment over a few months. The length of your treatment and the number of cycles you have will depend on the type of cancer for which you are being treated. Your nurse or doctor will discuss your treatment plan with you.Possible side effectsEach person’s reaction to chemotherapy is different. Some people have very few side effects, while others may experience more.The side effects described here won’t affect everyone who is given amsacrine, and may be different if you are having more than one chemotherapy drug.We have outlined the most common side effects and also some of the rarer ones, so that you can be aware of them if they occur. However, we haven’t included those that are very rare and therefore extremely unlikely to affect you. If you notice any effects that are not listed in this information, please discuss them with your doctor or nurse.Feeling sick (nausea) and being sick (vomiting) This may begin a few hours after the treatment is given and last for up to a day. Your doctor can prescribe very effective anti-sickness(anti-emetic) drugs to prevent or greatly reduce nausea and vomiting| .If the sickness isn’t controlled, or if it continues, tell your doctor; they can prescribe other anti-sickness drugs which may be more effective.Some anti-sickness drugs can cause constipation. Let your doctor or nurse know if this is a problem.Lowered resistance to infectionAmsacrine can reduce the production of white blood cells by the bone marrow, making you more prone to infection| .This effect can begin seven days after treatment has been given, and your resistance to infection usually reaches its lowest point 11-13 days after chemotherapy. The number of your white blood cells will then increase steadily and usually returns to normal levels before yournext course of chemotherapy.Contact your doctor or the hospital straight away if:your temperature goes above 38°C (100.4°F)you suddenly feel unwell (even with a normal temperature).You will have a blood test before having more chemotherapy to make sure that your cells have recovered. Occasionally, it may be necessary to delay your treatment if the number of blood cells (the blood count) is still low.Bruising or bleedingAmsacrine can reduce the production of platelets, which help the blood to clot and stop bleeding. Let your doctor know if you have any unexplained bruising or bleeding, such as nosebleeds, blood spots or rashes on the skin, or bleeding gums.Anaemia (low number of red blood cells)While having treatment with amsacrine you may become anaemic. This may make you feel tired| and breathless| . Let your doctor or nurse know if you develop these symptoms.Discoloured urineYour urine may become an orange colour. This may last up to 24 hours after you have had amsacrine and is due to the colour of the drug.It’s normal and nothing to worry about.Tiredness and feeling weakYou may feel very tired| . It’s important to allow yourself plenty of time to rest.Less common side effectsDiarrhoeaThis can usually be controlled with medicine, but let your doctor know if it is severe or if it continues. It is important to drink plenty of fluids if you have diarrhoea| .Hair lossIf your hair falls out it usually starts 3-4 weeks after the first dose of amsacrine, although it may happen earlier. Your hair might fall out completely or may just get thinner. You may also have thinning and loss of your eyelashes, eyebrows and other body hair.Hair loss| is temporary and your hair will regrow once the treatment ends.Your nurse can give you advice about coping with hair loss.Mouth sores and ulcersYour mouth may become sore| , or you may notice small ulcers during this treatment. Drinking plenty of fluids, and cleaning your teeth regularly and gently with a soft toothbrush, can help to reduce the risk of this happening. Tell your nurse or doctor if you have any ofthese problems, as they can prescribe special mouthwashes and medicines, which prevent or clear mouth infections.Taste changesYou may notice that your food tastes different. Normal taste will usually come back after the treatment finishes.Abdominal painLet your doctor know if you develop any abdominal (tummy) pain.It can usually be controlled with mild painkillers.Pain and swelling at the injection site If you feel pain, tell the doctor or nurse. They can slow the drip, which should reduce the feeling.Changes to the normal rhythm of the heart If this happens, it’s usually temporary and can be reversed with medication. Your heart function is likely to be checked before treatment starts. You will also have regular blood tests to check the chemicals in the blood, as changes in the level of one of these chemicals (potassium) can affect the normal rhythm of the heart.Additional informationInjection siteIf the area around the injection site becomes red or swollen you should tell the nurse or doctor on the ward. If you are at home, ring the clinic or ward and ask to speak to someone.Risk of blood clotsCancer can increase your risk of developing a blood clot(thrombosis), and having chemotherapy may increase this risk further. A blood clot may cause symptoms such as pain, redness and swelling in a leg, or breathlessness and chest pain. Blood clots can be very serious, so it’s important to tell your doctor straight away if you have any of these symptoms. However, most clots can be treated with drugs that thin the blood.Your doctor or nurse can give you more information.Other medicinesSome medicines, including those you can buy in a shop or a chemist, can be harmful to take when you are having chemotherapy. Let your doctor know about any medicines you are taking, including over-the-counter drugs, complementary therapies and herbal drugs.FertilityYour ability to become pregnant or father a child may be affected by taking this drug. It’s important to discuss fertility| with your doctor before starting treatment.ContraceptionIt’s not advisable to become pregnant or father a child while taking amsacrine as it may harm the developing foetus.It is important to use effective contraception whilst taking this drug, and for at least a few months afterwards. Again, discuss this with your doctor.