替尼泊苷注射剂Teniposide(Vumon Injection 10mg)

产地国家:美国

处方药:是

所属类别:10毫克/毫升 5毫升/安醅

包装规格:10毫克/毫升 5毫升/安醅

计价单位:瓶

生产厂家英文名:BRISTOL MYERS SQUIBB

原产地英文商品名:VUMON 10MG/ML 5ML/AMPUL

原产地英文药品名:TENIPOSIDE

中文参考商品译名:卫萌 10毫克/毫升 5毫升/安醅

中文参考药品译名:替尼泊苷

简介

部份中文替尼泊苷处方资料(仅供参考)

商品名:Vumon

英文名: Teniposide

别名:替尼泊苷;威猛;维埃坶26;足叶毒硫花亚甲基葡萄糖苷,邦莱,鬼臼噻吩甙

外文名:Teniposide,Vumon,VM-26

制造商:百时美施贵宝

药物分类:抗肿瘤药

适应症:本品是一种半合成的鬼臼脂毒,可阻止S后期或G期细胞,但机理不清楚。可能是通过鬼臼噻吩甘与拓扑异构酶-Ⅱ结合,主要用于何杰金和非何杰金淋巴瘤有明显效应。对儿童淋巴细胞性白血病也有作用。

用量用法:静脉注射,每次每千克体重1~3mg,每周2次,可给药2~3个月。

注意事项

1.胃肠道反应如恶心、呕吐、食欲不振等。

2.有骨髓抑制副作用,需经常注意血象的变化。

3.少数病人有过敏反应及脱发等。

规格针剂:每支50mg(5ml)。

英文版说明书

GENERIC NAME: TENIPOSIDE – INJECTION (ten-IP-oh-side)BRAND NAME(S): VumonWARNING: This medication may cause certain severe blood and bone marrow problems (low red blood cells/white blood cells/platelets). This can affect your body’s ability to stop bleeding or fight infection.Tell your doctor immediately if you develop easy bleeding/bruising or signs of infection (e.g., fever, chills, persistent sore throat).This medication can also cause a serious allergic reaction.Your health care professional will monitor you closely during treatment for any signs of a reaction. (See also Side Effects section)USES: This medication is used with other anti-cancer drugs to treat leukemia and certain cancers. Teniposide works by slowing or stopping the growth of cancer cells.HOW TO USE: Follow all instructions for proper mixing with the correct IV fluids. Before using, check the product visually for particles or discoloration.If either is present, do not use the liquid. Particles may form while the drug is being given, especially if it is given over many hours. Read the product labeling to learn how to prevent particles from forming/entering the blood.This medication is given by slow injection into a vein by a health care professional over at least 30 to 60 minutes, usually once or twice a week or as directed by your doctor.This medication may cause low blood pressure. Tell your doctor or other health care professional if you feel dizzy. Your injection may need to be stopped or given more slowly.Dosage is based on your medical condition, body size, and response to treatment. Your doctor will check your blood counts to make sure you can receive your next dose. Be sure to keep all medical/lab appointments.If this medication accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged.Tell your doctor immediately if you feel pain or irritation at theinjection site.Wear gloves when handling this medication.If this medication touches your skin, immediately wash the area well with soap and water. If this medication gets in your eye, open theeyelids and flush with water, then seek immediate medicalattention.Learn how to store and discard needles, medical supplies, and medical waste safely.Consult your pharmacist for details.SIDE EFFECTS: See also Warning section.Nausea, vomiting, diarrhea, drowsiness, and pain/redness at the injection site may occur.Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist orworsen, tell your doctor or pharmacist promptly.Temporary hair loss may occur. Normal hair growth should return after treatment has ended.Many people using this medication may have serious side effects. However, your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. To lower your risk of serious side effects,your doctor will follow your condition closely and order lab tests.Pain or sores in the mouth and throat may occur.Brush your teeth gently/carefully, avoid using mouthwash that contains alcohol, and rinse your mouth frequently with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.Tell your doctor immediately if any of these unlikely but serious side effects occur: dizziness/fainting, bloody/black/tarry stool, unusualweakness/tiredness, coughing up blood.Tell your doctor immediatelyif any of these rare but very serious side effects occur: severe abdominal pain, slow/shallow breathing, mental/mood changes (e.g., confusion, difficulty staying awake).A very serious allergic reaction to this drug is unlikely. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: fast/irregular heartbeat, flushing of the face, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, fever/chills.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.PRECAUTIONS: Before using teniposide, tell your doctor or pharmacistif you are allergic to it; or to polyoxyethylated castor oil; or ifyou have any other allergies.Tell your doctor your medical history,especially of: current infections, certain virus illnesses (herpes,chickenpox), liver problems, kidney problems, blood disorders (e.g.,anemia, clotting problems), Down syndrome, low blood proteins (hypoalbuminemia).This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.Wash your hands well to prevent the spread of infections.Avoid contact with people who have illnesses that may spread toothers (e.g., flu, chickenpox).To lower your chance of getting cut,bruised, or injured, use caution with sharp objects like razors andnail cutters, and avoid activities such as contact sports.This product contains alcohol. Caution is advised if you have alcoholdependence or liver disease. Ask your doctor or pharmacist about using this product safely.This drug is not recommended for use during pregnancy. It may harm the unborn baby.If you become pregnant or think you may be pregnant, tell your doctor immediately.To avoid pregnancy, both males and females using this drug shoulduse reliable form(s) of birth control (e.g., birth control pills, condoms) during treatment. Consult your doctor for details and to discuss effective forms of birth control.It is not known whether this medication passes into breast milk. However, it may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.DRUG INTERACTIONS:Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: live vaccines (e.g., flu vaccine inhaled through the nose, typhoid/polio vaccine taken by mouth).If you are currently receiving or planning any vaccinations, tell your doctor or pharmacist before starting teniposide.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: “blood thinners” (e.g., warfarin, enoxaparin), salicylates/NSAIDs (e.g., aspirin, ibuprofen, naproxen, sodium salicylate), drugs that may interact with alcohol(e.g., disulfiram, metronidazole), tolbutamide, methotrexate, sulfonamide antibiotics (e.g., sulfamethizole).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs(e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) becausethey may contain ingredients that cause drowsiness.Ask your pharmacist about using those products safely.Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) that can increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day). Consult your doctor or pharmacist for more details.This document does not contain all possible interactions. Therefore,before using this product, tell your doctor or pharmacist of all theproducts you use. Keep a list of all your medications with you, andshare the list with your doctor and pharmacist.OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.NOTES: Laboratory and/or medical tests (e.g., complete blood count,liver tests, kidney tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.MISSED DOSE: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed.If you miss a dose, contact your doctor to establish a new dosing schedule. Do not double the dose to catch up.STORAGE: Store in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture. Do not store in the bathroom. After mixing, do not refrigerate. Discard any unused liquid/solution. Do not save for later use. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information a

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