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硫酸氢氯吡格雷阿司匹林_ComPlavin_硫酸氢氯吡格雷阿司匹林配合錠说明书

 

ComPlavin Combination Tablets(硫酸氢氯吡格雷阿司匹林配合錠)

药店国别:

产地国家:日本

处 方 药:

所属类别:100片/盒

包装规格:100片/盒

计价单位:

生产厂家中文参考译名:赛诺菲公司

生产厂家英文名:Sanofi K.K

原产地英文商品名:ComPlavin Combination 75mg/100mg/Tablets 100Tablets/box

原产地英文药品名:Clopidogrel Sulfate/Aspirin

中文参考商品译名:ComPlavin复合片 75毫克/100毫克/片 100片/盒

中文参考药品译名:硫酸氯吡格雷/阿司匹林

简介:

部份中文硫酸氢氯吡格雷/阿司匹林处方资料(仅供参考)

治疗类别名称:抗血小板剂

批准上市:2013年

英文名称:Clopidogrel sulfate and Aspirin Tablets

商品名:DuoCover、DuoPlavin

药效药理

1. 薬理作用

(1) 根据血小板由ADP刺激活化硫酸氯吡格雷不表达在体外血小板凝集抑制作用,口服给药后,和由肝脏代谢成为活性代谢物,抑制血小板聚集。在大鼠还已经由胶原和低浓度的凝血酶观察血小板聚集的抑制。

(2) 硫酸氯吡格雷是,中脑动脉血栓形成模型(大鼠),动静脉分流模型(大鼠),冠状动脉周期性血流减少模型(犬),颈动脉球囊内皮损伤模型(兔),支架放置动静脉分流模型抑制(兔)的血栓形成,它是在大脑中动脉脑模型通过减少血栓形成抑制的基础上的梗塞大小。结合阿司匹林当用于颈动脉球囊内皮损伤模型中,在支架的动静脉分流模型血栓形成的抑制效果提高。

2. 作用机序

(1) 硫酸氯吡格雷活性代谢物,不可逆地抑制ADP的结合影响血小板ADP受体亚型P2Y1227),抑制基于血小板的活化血小板聚集。

(2) 阿司匹林通过抑制环氧合酶,抑制血栓烷A2的合成,抑制血小板聚集。

适应症:对已服用过氯吡格雷和阿司匹林患者的动脉粥样硬化有预防作用;非ST段抬高性急性冠脉综合征(包括不稳定性心绞痛或非Q波心肌梗死),包括经皮冠状动脉介入术后置入支架的患者;用于ST段抬高性急性冠脉综合征患者,可合并在溶栓治疗中使用。

剂量与用法成人,每天一次,每次1片(100毫克为75毫克和阿司匹林作为氯吡格雷)口服给药

包装规格:100錠[10錠(PTP)×10]

生产厂家赛诺菲日本公司

优势:临床上目前临床治疗手段除介入治疗以外,阿司匹林+氯吡格雷的二联治疗是*的药物治疗手段。

 

Brand name:ComPlavin Combination Tablets

Active ingredient:Clopidogrel Salfate

Aspirin

Dosage form: white to pale yellow tablet, diameter: 11 mm, thickness: 6 mm

Print on wrapping: コンプラビン配合錠 ComPlavin saCA

Effects of this medicine

This medicine is a combination of the two active ingredients and inhibits platelet aggregation based on platelet activation, suppresses clot formation and prevents blockage of blood vessels.

It is usually used for acute coronary syndrome, stable angina pectoris and old myocardial infarction for which percutaneous coronary intervention is indicated.

Before using this medicine, be sure to tell your doctor and pharmacist

•If you have previously experienced any allergic reactions (asthma, itch, rash, etc.) to any medicines.

•If you have bleeding, pain or tenderness in the solar plexus, heartburn, belching, nausea, vomiting, hematemesis and melena.

•If you are going to undergo dental extraction or surgery.

•If you are pregnant or breastfeeding.

•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

•Your dosing schedule prescribed by your doctor is <>

•In general, for adults, take 75 mg as clopidogrel and 100 mg as aspirin once a day from the date of first administration. Strictly follow the instructions.

•If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time. in general, for adults, take this medicine once a day. Strictly follow the instructions. Avoid taking this medicine on an empty stomach. Take this medicine as it is without breaking, chewing and crunching.

•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.

•Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

• Possible adverse effects of this medicine

The most commonly reported adverse reactions include bleeding tendency including subcutaneous bleeding, nausea/vomiting and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

•sudden severe headache, nausea/vomiting, one-sided face or limbs paralysis[intracranial bleeding, subdural hematoma]

•melena (black stool, bloody stool), hematemesis, vision disorder, joint pain[hematemesis, melena, gastrointestinal bleeding, ocular fundus bleeding, joint hematoma, lung bleeding]

•severe fatigue/malaise, loss of appetite, yellow discoloration of the white of the eyes/the skin[liver dysfunction, jaundice]

•malaise, loss of appetite, purpura, disturbed consciousness[thrombotic thrombocytopenic purpura]

•sore throat, headache/feeling of dull headache, ear ringing[thrombocytopenia, leukopenia, agranulocytosis, pancytopenia]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

•Keep this medicine out of the reach of children. Store away from direct sunlight, heat and moisture.

•Discard the remainder. Do not store them.

用药温馨提示:当您服用此药物时,需定期接受医疗专业人士的检查,以便随时针对其药效、副作用等情况进行监测。本网站所包含的信息旨在为患者提供帮助,不能代替医学建议和治疗。
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