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凝血酶_Thrombin_凝血酶口服微粒说明书


THROMBIN Oral fine gran 2g BAG(Thrombin 凝血酶口服微粒)

  药店国别:

  产地国家:日本

  处 方 药:

  所属类别:2克/包 30包/盒

  包装规格:2克/包 30包/盒

  计价单位:

  生产厂家中文参考译名:泽井药业

  生产厂家英文名:Sawai Pharmaceutical Co

  原产地英文商品名:THROMBIN Oral Fine Granules 2g/bag 30bag/box

  原产地英文药品名:Thrombin

  中文参考商品译名:THROMBIN口服微粒 2克/包 30包/盒

  中文参考药品译名:凝血酶

  简介:

  部份中文凝血酶处方资料(仅供参考)

  治疗类别名称:上消化道的止血剂

  商標名:THROMBIN

  通用名称:凝血酶

  成份:本品为牛血或猪血中提取的凝血酶原,经激活而得凝血酶的无菌冻干品。每1mg效价不得少于10单位。含凝血酶应为标示量的80%以上。

  性状:本品为白色或类白色的冻干块状物或粉末。每1ml中含500单位的0.9%氯化钠溶液微显浑浊。

  药理毒理:促使纤维蛋白原转化为纤维蛋白,应用于创口,使血液凝固而止血。

  适应症:用于手术中不易结扎的小血管止血、消化道出血及外伤出血等。

  用法和用量:

  1、局部止血用灭菌氯化钠注射液溶解成50~200单位/ml的溶液喷雾或用本品干粉喷洒于创面。

  2、消化道止血用生理盐水或温开水(不超37℃)溶解成10~100单位/ml的溶液,口服或局部灌注,也可根据出血部位及程度增减浓度、次数。

  不良反应:

  (1)偶可致过敏反应,应及时停药。

  (2)外科止血中应用本品曾有致低热反应的报道。

  禁忌:对本品有过敏史者禁用。

  注意事项:

  (1)本品严禁注射。如误入血管可导致血栓形成、局部坏死危及生命。

  (2)本品必须直接与创面接触,才能起止血作用。

  (3)本品应新鲜配制使用。

  孕妇及哺乳期妇女用药:孕妇只在具有明显指征,病情必需时才能使用。

  药物相互作用:

  (1)本品遇酸、碱、重金属发生反应而降效。

  (2)为提高上消化道出血的止血效果,宜先服一定量制酸剂中和胃酸后口服本品,或同时静脉给予抑酸剂。

  (3)本品还可用磷酸盐缓冲液(pH7.6)或冷牛奶溶解。如用阿拉伯胶、明胶、果糖胶、蜂蜜等配制成乳胶状溶液,可提高凝血酶的止血效果,并可适当减少本品用量。

  贮藏:密封,在4℃~10℃保存。

  包装规格:

  細粒

  5000单位:30包(1包0.5克)

  10000单位:30包(1包1G)

  200单位:30包(1包2G)

  制造厂商:泽井药业有限公司

  THROMBIN Oral Fine Granules

  Brand name : THROMBIN Oral Fine Granules 10,000 Units

  Active ingredient: Thrombin

  Dosage form: white fine granules

  Effects of this medicine

  This medicine is an enzyme related to blood coagulation and has the effect to stop bleeding from tissue surface.

  It is usually used to treat upper gastrointestinal bleeding.

  Before using this medicine, be sure to tell your doctor and pharmacist

  •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.

  •If you are pregnant or breastfeeding.

  •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

  Dosing schedule (How to take this medicine)

  •Your dosing schedule prescribed by your doctor is <>

  •Gastric acid needs to be neutralized using a buffering agent (milk, phosphate buffer solution, etc.) before this medicine is taken. First, take approximately 50 mL of the buffering agent. Five minutes later, take this medicine after dissolving 1 to 2 packets (10,000 to 20,000 units of the active ingredient) with approximately 50 mL of the buffering agent. However, the dosage may be adjusted according to the sites and severity of bleeding. Strictly follow the instructions.

  •Take this medicine immediately after opening the packet and dissolving with the buffering agent. The solution may become slightly cloudy, but the effect of this medicine will not be affected.

  •If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. You should never take two doses at one time.

  •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.

  •Do not stop taking this medicine unless your doctor instructs you to do so.

  Precautions while taking this medicine

  • Possible adverse reactions to this medicine

  The most commonly reported adverse reactions include abdominal bloating, diarrhea, nausea, vomiting, fever, rash, redness and headache. If any of these symptoms occur, consult with your doctor or pharmacist.

  The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

  •respiratory distress, bluish purple to dark purple discoloration of the skin and mucosa (especially lips and nails of limbs), dizziness on standing up [shock]

  •prolonged bleeding, bleeding tendency [clotting disorder, abnormal bleeding]

  The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

  Storage conditions and other information

  •Keep out of the reach of children. Store away from direct sunlight, heat and moisture.

  •Discard the remainder. Do not store them.

  Sawai Pharmaceutical Co.,Ltd.Internal

  Revised: 10/2008

  The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

用药温馨提示:当您服用此药物时,需定期接受医疗专业人士的检查,以便随时针对其药效、副作用等情况进行监测。本网站所包含的信息旨在为患者提供帮助,不能代替医学建议和治疗。
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