卡莫司汀Carmustine(GLIADEL 7.7mg/Implant)

产地国家日本

处方药

所属类别  7.7mg/枚 8枚/盒

包装规格  7.7mg/枚 8枚/盒

计价单位

生产厂家英文名Eisai Co. Ltd.

原产地英文商品名Gliadel Implant 7.7mg/piece 8pieces/bag

原产地英文药品名Carmustine

中文参考商品译名Gliadel植入片(ギリアデル脳内留置用剤)7.7mg/枚 8枚/包(分包1枚×8)

中文参考药品译名卡莫司汀

简介:

部份中文卡莫司汀处方资料(仅供参考)

英文药名Gliadel 7.7mg Implant(Carmustine)

中文药名:卡莫司汀植入片

生产厂家:卫材

药物分类名称:抗肿瘤药

批准日期:2012年11月

商标名:Gliadel 7.7mg Implant

一般名:カルムスチン(Carmustine)

化学名:1,3-Bis(2-chloroethyl)-1-nitrosourea

分子式:C5H9Cl2N3O2

分子量:214.05

性状:它是一种淡黄色粉末。它非常易溶于二甲基亚砜,乙醇(95),二氯甲烷或乙腈,易溶于丙二醇,甲醇或无水二乙醚,不容易溶于水。熔点约31°C处理注意事项当卡莫司汀与皮肤接触时,可能会引起严重的灼伤和色素沉着,因此在处理本产品时要小心。

药效药理:1.抗肿瘤效果已经证明卡莫司汀可以延长其移植有人成胶质细胞瘤的U-87MG细胞系的小鼠的存活时间。2.作用机序据信卡莫司汀通过烷化DNA和抑制核酸合成来诱导细胞周期停滞和凋亡。

适应病症:恶性胶质瘤、脑瘤

用法与用量:通常取决于肿瘤切除的腔的大小和形状,成年人在切除脑肿瘤时覆盖切除的表面,8片这种药物(61.6mg,作为卡莫司汀)或数量减少。

包装规格:Giadiadel脑残留剂7.7毫克8片(1包×1×8)4张(1件包装×4张)1张(每包1件)

英文版说明书:

Eyre implanted antineoplastic drugs are listed in JapanNobelpharma and Eisai’s implantable antineoplastic agent 7.7 mg Gliadel (Caramustine) was listed on Jan. 9 in Japan. Nobelpharma has completed a clinical study and obtained manufacturing and marketing rights in Japan on September 28, 2012 and was registered with the National Health Insurance (NHI) Drug List on 22 November 2012. 7.7 mg Gliadel implants were promoted by cooperation between the two companies in Japan.Gliadel in Japan is the only approved slow-release preparation for intracranial implantation. Each wafer contains bischloroethylnitrosourea, an alkylation of nitrosourea, dispersed in a biodegradable polymer matrix. Malignant glioma resection after implantation of the wafer, can make chemotherapy drugs can be directly transmitted to the tumor site.Gilladel’s significant diagnosis of newly diagnosed malignant gliomas significantly increased patient survival compared with placebo in a three-phase study conducted outside of Japan, whereas for patients with recurrent neuroblastoma after 6 months of total Survival rates also increased significantly.Gliadel has now been approved in 30 countries around the world, including the United States, Europe and Southeast Asia.Glioma is a brain tumor that accounts for 30% of all primary brain tumors. The incidence of malignant gliomas in Japan is estimated to be about 2000 to 2500 per year. Gliadel was designated as a high demand drug by the Japanese Drug Unregistered Usage Committee in September 2008 and was designated as orphan drug in June 2009.

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