甲氨喋呤，甲氨喋呤注射液（Methotrexat Proreo Inj）
药店国别：无 产地国家：瑞士 处方药：是 所属类别： 10毫克/毫升/安醅 10安醅/盒 包装规格： 10毫克/毫升/安醅 10安醅/盒 计价单位：盒 生产厂家中文参考译名：无 生产厂家英文名：Curatis AG 原产地英文商品名：Methotrexat Proreo Inj 10Mg/ml/Ampul 10Ampul/box 原产地英文药品名：Methotrexat 中文参考商品译名：Methotrexat注射液 10毫克/毫升/安醅 10安醅/盒 中文参考药品译名：甲氨喋呤 曾用名：无
简介部份中文甲氨喋呤处方资料（仅供参考） 药品名称：甲氨喋呤注射液 汉语拼音：Jia‘andieling Zhusheye 英文名：Methotrexate 剂型：注射剂 主要成分 本品主要成分为甲氨喋呤。 适应症 适用于急性白血病、乳腺癌、绒毛膜上皮癌及恶性葡萄胎、头颈部肿瘤、骨肿瘤、白血病脑膜脊髓浸润、肺癌、生殖系统肿瘤、肝癌、顽固性普通牛皮癣、自体免疫病。 用法用量 用剂量为15～30mg口服或肌注，连用5天。如果所有毒性体征均已消失。经过一或多周期，可给予次一疗程。一般应用3～5疗程。治疗的疗效一般由24小时尿中绒毛膜促性腺激素（CGH）的定量分析来估价，此值必须恢复到正常或低于每24小时50IU，一般经3～4疗程后达到，一般在4～6周后可测量的病变发生完全消散。一般推荐在CGH正常化后再用1～2疗程。 每个用药疗程前，小心的临床估价是必要的。甲氨蝶呤与其他化疗药合用循环联合化疗均曾报告作为很常用的。 药理相互作用 可与叶酸、水杨酸盐、保泰松、苯妥英、**类、磺胺类、皮质类固醇激素、四环素、氯霉素、对氨基苯甲酸、丙磺舒发生相互作用。 制剂：注射液：1 g X 1 瓶 50 mg X 1 瓶 500 mg X 1 瓶 储藏 ：25℃以下避光保存。
英文版说明Methotrexate InjectionIMPORTANT WARNING:Expand SectionMethotrexate may cause very serious, life-threatening side effects. You should only receive methotrexate injection to treat life-threatening cancer, or certain other conditions that are very severe and that cannot be treated with other medications.Talk to your doctor about the risks of receiving methotrexate injection for your condition.Tell your doctor if you have or have ever had excess fluid in your stomach area or in the space around your lungs and if you have or have ever had kidney disease.Also tell your doctor if you are taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), or salsalate.These conditions and medications may increase the risk that you will develop serious side effects of methotrexate.Your doctor will monitor you more carefully and may need to give you a lower dose of methotrexate or stop your treatment with methotrexate.Methotrexate may cause a decrease in the number of blood cells made by your bone marrow.Tell your doctor if you have or have ever had a low number of any type of blood cells or any other problem with your blood cells.Call your doctor immediately if you experience any of the following symptoms: sore throat, chills, fever, ongoing cough and congestion, or other signs of infection; unusual bruising or bleeding; unusual tiredness or weakness; pale skin; or shortness of breath.Methotrexate may cause liver damage, especially when it is taken for a long period of time.Tell your doctor if you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease.Your doctor may not want you to receive methotrexate injection unless you have a life-threatening form of cancer because there is a higher risk that you will develop liver damage.The risk that you will develop liver damage may also be higher if you are elderly, obese, or have diabetes.Ask your doctor about the safe use of alcoholic beverages while you are receiving methotrexate injection.Tell your doctor if you are taking any of the following medications: acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), or tretinoin (Vesanoid). Call your doctor immediately if you experience any of the following symptoms: nausea, extreme tiredness, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or flu-like symptoms.Your doctor may order liver biopsies (removal of a small piece of liver tissue to be examined in a laboratory) before and during your treatment with methotrexate.Methotrexate may cause lung damage. Tell your doctor if you have or have ever had lung disease.Call your doctor immediately if you experience any of the following symptoms: dry cough, fever, or shortness of breath.Methotrexate may cause damage to the lining of your mouth, stomach or intestines.Tell your doctor if you have or have ever had stomach ulcers or ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum).Call your doctor immediately if you experience any of the following symptoms: mouth sores, diarrhea, black, tarry, or bloody stools, and vomiting, particularly if vomit is bloody or looks like coffee grounds.Using methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system).If you do develop lymphoma, it might go away without treatment when you stop taking methotrexate, or it might need to be treated with chemotherapy.If you are taking methotrexate to treat cancer, you may develop certain complications that may be serious or life-threatening as methotrexate works to destroy the cancer cells.Your doctor will monitor you carefully and treat these complications if they occur.Methotrexate may cause serious or life-threatening skin reactions.If you experience any of the following symptoms, call your doctor immediately: fever, rash, blisters, or peeling skin.Methotrexate may decrease the activity of your immune system, and you may develop serious infections.Tell your doctor if you have any type of infection and if you have or have ever had any condition that affects your immune system.Your doctor may tell you that you should not receive methotrexate unless you have life-threatening cancer.If you experience signs of infection such as a sore throat, cough, fever, or chills, call your doctor immediately.If you receive methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body.Keep all appointments with your doctor and the laboratory.Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe.Tell your doctor if you or your partner is pregnant or plan to become pregnant.If you are female, you will need to take a pregnancy test before you receive methotrexate. Use a reliable method of birth control so that you or your partner will not become pregnant during or shortly after your treatment.If you are male, you and your female partner should continue to use birth control for 3 months after you stop using methotrexate.If you are female, you should continue to use birth control until you have had one menstrual period that began after you stopped using methotrexate.If you or your partner become pregnant, call your doctor immediately. Methotrexate may cause harm or death to the fetus.Why is this medication prescribed?Expand SectionMethotrexate injection is used alone or in combination with other medications to treat gestational trophoblastic tumors (a type of tumor that forms inside a woman's uterus while she is pregnant), breast cancer, lung cancer, certain cancers of the head and neck; certain types of leukemia (cancer of the white blood cells), including acute lymphocytic leukemia (ALL) and meningeal leukemia (cancer in the covering of the spinal cord and brain); certain types of non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); and osteosarcoma (cancer that forms in bones) after surgery to remove the tumor.Methotrexate injection is also used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments.Methotrexate injection is also used along with rest, physical therapy and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications.Methotrexate is in a class of medications called antimetabolites.Methotrexate treats cancer by slowing the growth of cancer cells. Methotrexate treats psoriasis by slowing the growth of skin cells to stop scales from forming.Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system.How should this medicine be used?Expand SectionMethotrexate injection comes as a powder to be mixed with liquid to be injected intramuscularly (into a muscle), intravenously (into a vein), intra-arterially (into an artery), or intrathecally (into the fluid-filled space of the spinal canal).The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have.Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.Other uses for this medicineExpand SectionMethotrexate is also sometimes used in combination with other medications to treat bladder cancer.It is also sometimes used to treat Crohn's disease (condition in which the immune system attacks the lining of the digestive tract, causing pain, diarrhea, weight loss and fever) and other autoimmune diseases (conditions that develop when the immune system attacks healthy cells in the body by mistake). Ask your doctor about the risks of using this medication for your condition.This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.What special precautions should I follow?Expand SectionBefore receiving methotrexate injection,•tell your doctor and pharmacist if you are allergic to methotrexate, any other medications, or any of the ingredients in methotrexate injection. Ask your pharmacist for a list of the ingredients.•tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: certain antibiotics such as chloramphenicol (Chloramycetin), penicillins, and tetracylcines; folic acid (available alone or as an ingredient in some multivitamins); other medications for rheumatoid arthritis; phenytoin (Dilantin); probenecid (Benemid); proton pump inhibitors (PPIs) such as esomeprazole (Nexium), omeprazole (Prilosec, Prilosec OTC, Zegerid), pantoprazole (Protonix); sulfonamides such as co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), and sulfisoxazole (Gantrisin); and theophylline (Theochron, Theolair). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.•tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or a low level of folate in your blood.•do not breastfeed while you are receiving methotrexate injection.•you should know that methotrexate may cause dizziness or make you feel drowsy. Do not drive a car or operate machinery until you know how this medication affects you.•plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Methotrexate may make your skin sensitive to sunlight or ultraviolet light. If you have psoriasis, your sores may get worse if you expose your skin to sunlight while you are receiving methotrexate.•do not have any vaccinations during your treatment with methotrexate without talking to your doctor.What special dietary instructions should I follow?Expand SectionUnless your doctor tells you otherwise, continue your normal diet.What side effects can this medication cause?Expand SectionMethotrexate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:•joint or muscle pain•reddened eyes•swollen gums•hair lossSome side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:•vomiting•blurred vision or sudden loss of vision•sudden fever, severe headache, and stiff neck•seizures•confusion or memory loss•weakness or difficulty moving one or both sides of the body•difficulty walking or unsteady walking•loss of consciousness•impaired speech•decreased urination•swelling of the face, arms, hands, feet, ankles, or lower legs•hives•itching•skin rash•difficulty breathing or swallowingMethotrexate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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