甲氨喋呤胶囊Methotrexate (Rheumatrex capsules 60×2mg)

药店国别:

产地国家:日本

处方药:

所属类别: 2毫克/胶囊 60胶囊/盒

包装规格: 2毫克/胶囊 60胶囊/盒

计价单位:

生产厂家中文参考译名:

生产厂家英文名:Pfizer Japan Inc

原产地英文商品名:RHEUMATREX(リウマトレックスカプセル)2mg/CAPSULES 60CAPSULES/box

原产地英文药品名:Methotrexate

中文参考商品译名:RHEUMATREX(リウマトレックスカプセル)2毫克/胶囊 60胶囊/盒

中文参考药品译名:甲氨喋呤

曾用名:

简介

部份中文甲氨喋呤处方资料(仅供参考)

英文名:Methotrexate

商品名:RHEUMATREX CAPSULES

中文名:甲氨喋呤胶囊

生产商:辉瑞制药

药物类别名称:抗风湿剂

批准日期:1999年5月

商标名:RHEUMATREX CAPSULES 2mg

一般名:メトトレキサート(Methotrexate)

化学名:N-{4-[(2,4-Diaminopteridin-6-ylmethyl)(methyl)amino]benzoyl}-L-glutamic acid

構造式分子式:C20H22N8O5

分子量:454.44

性状:本产品为褐色结晶粉末。本产品可溶于二甲苯、水、乙酰乙酸酯、乙醇(95)或二乙醚。本产品溶解在稀有氢氧化钠测试溶液或稀钠碳酸钠测试溶液中。本产品逐渐由光改变。

药用药理学

1. 支持疗效的药理学测试大鼠慢性关节炎模型的药用特性甲氨蝶酯用于胶原蛋白关节炎,0.05和0.1mg/kg /天剂量和0.6~1.2mg/kg/周3周分管,反复施用扩大后肢肿胀抑制,改善体重增加抑制,显示这种骨破坏抑制的效果。此外,慢性后肢肿胀和骨破坏裂解细胞壁诱发关节炎是一种辅助性关节炎被抑制在重复的0.125mg/kg /天。 它被间歇性口服给塞0.15~0.6mg/kg/周或0.375mg/kg/3周抑制,用于未治疗的辅助性关节炎足部炎症。

2. 作用机制甲氨蝶酯免疫球蛋白在体外生产人单核细胞,抑制小鼠脾细胞的抗羊红细胞抗体产生。此外,通过抑制小鼠脾细胞的DNA合成活性,被认为具有淋巴细胞生长抑制作用。甲氨蝶酯由于抑制血管内皮细胞和体外成纤维细胞的生长,被认为能抑制血管生成和阴膜生长。

甲氨蝶酯抑制中性粒细胞在体内的炎症部位运行。 中性粒细胞减少症的作用抑制作用,细胞粘附抑制作用对中性粒细胞腺苷释放成纤维细胞和血管内皮细胞通过甲氨蝶酯的作用,具有很强的中性粒细胞运行活性,可以想象,白细胞介素B4的产生抑制,这也是已知的自由作用的索贝酶。作为细胞因子的一种作用,甲氨蝶酯被抑制白细胞素-1(IL-1)的巨噬细胞生产增强在辅助性关节炎模型大鼠口服。另一方面,参与破坏肌膜组织和软骨组织的甲氨蝶酯胶原酶的产生被体外抑制(人阴纤维细胞),在类风湿性关节炎患者中甲氨蝶酯治疗酶酶酶mRNA表达被抑制。

3. 单侧肾切除术鼠的亚急性毒性试验对一侧肾的假手术大鼠进行28天重复口服毒性试验,对甲氨蝶酯进行0.06、0.2、0.6mg/kg/天的对照和控制。在采肾大鼠中,死亡和死亡动物的数量很高,在肾腌大鼠之前,一般状态的异常表示。肾采摘大鼠的无毒量为0.06毫克/千克/日,假手术鼠的毒性为0.06毫克/千克/天。

4. 与非类固醇抗炎剂结合毒性使用雌性大鼠同时重复口服28天,同时重复口服,对甲氨蝶酯和三氯苯甲酸钠、甲氨蝶酯0.2、0.4、0.6mg/kg/天和三氯芬酸钠的毒性进行检测。死亡和死亡动物的数量高于仅甲氨蝶酯组的数量。 异常发现的频率和程度,如异常和一般状态的组织病理学测试往往增加或变得严重比甲氨蝶酯单独组。

5. 肺毒性检查甲氨蝶酯的肺毒性用于大鼠,通过支气管肺泡清洗和肺部组织病理学搜索进行检查。甲氨蝶酯给剂,虽然发现一半的垂死动物肺部感染的细菌质量,但未观察到被感染病变的病灶,如肺泡壁增厚和出血。感染是由永久性细菌引起的机会性感染。虽然在阿尔韦拉尔腔中渗出的个体中观察到轻度炎症细胞渗透,但观察到大量淋巴细胞和嗜酸性粒细胞的渗透。此外,在无菌大鼠中同样轻度肺泡壁增厚,肺水肿和出血,肺泡巨噬菌体增加。

适应症

风湿性关节炎银屑病庸俗性不足以有效治疗局部治疗银屑病动脉病, 银屑病脓毒症, 银屑病红斑狼疮患有关节症状的少年特发性关节炎

用法与用量

*风湿性关节炎通常,每周单位和6mg的剂量作为甲氨蝶酯,口服通过将每周单位的剂量分成一两到三次。通过除以施用时,从第一天到第二天以12小时为间隔施用。在一两次分管剩余6天的情况下,其余5天分期3天暂停。 每周重复一次。

另外,病人的年龄,症状,但适当增加废弃,取决于反应或类似的反应和剂,以便不超过16mg作为一个星期的剂量。

*银屑病庸俗无效与局部治疗通常,每周单位和6mg的剂量作为甲氨蝶酯,口服通过将每周单位的剂量分成一两到三次。通过除以施用时,从第一天到第二天以12小时为间隔施用。在一两次分管剩余6天的情况下,其余5天分期3天暂停。每周重复一次。

另外,病人的年龄,症状,但适当增加废弃,取决于反应或类似的反应和剂,以便不超过16mg作为一个星期的剂量。

*牛皮病动脉病,银屑病脓毒症,银屑病红斑狼疮通常,每周单位和6mg的剂量作为甲氨蝶酯,口服通过将每周单位的剂量分成一两到三次。通过除以施用时,从第一天到第二天以12小时为间隔施用。在一两次分管剩余6天的情况下,其余5天分期3天暂停。 每周重复一次。

另外,病人的年龄,症状,但适当增加废弃,取决于反应或类似的反应和剂,以便不超过16mg作为一个星期的剂量。

*患有关节症状的少年特发性关节炎通常,每周单位剂量和4~10mg/m 2作为甲氨蝶酯,口服,将每周单位的剂量分成一至两至三次。通过除以施用时,从第一天到第二天以12小时为间隔施用。在一两次分管剩余6天的情况下,其余5天分期3天暂停。每周重复一次。

另外,病人的年龄,症状,适当增加或减少,这取决于反应或类似的反应,容忍和代理。

临床表现在日本总共46个设施中,150例类风湿性关节炎患者的临床试验结果,在6mg/每周给药组中,最终整体改善(显著改善和适度改善)的改善率为60.4%(32/53)。

包装:胶囊2mg: 30胶囊(PTP)2mg: 60胶囊(PTP)

制造和销售辉瑞有限公司注:以上中文处方资料不够完整,使用者以原处方资料为准。

 

英文版说明

view=frame&style=SGML&lang=jaRheumatrex (Methotrexate リウマトレックスカプセル2mg)Generic for Rheumatrex (Methotrexate) is used to treat certain types of cancer such as breast cancer, lung cancer, neck cancer, and skin cancer. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis. This medication works by interfering with the growth of certain cells of the body, as well as by suppressing the immune system.Recommended Dosage – Discount Prescription Drug Generic for RheumatrexThe dosage of Generic for Rheumatrex prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.Drink plenty of fluids while taking Generic for Rheumatrex tablets.Missed Dose of Generic for RheumatrexIf your physician has instructed or directed you to take Generic for Rheumatrex medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.Overdose of Generic for RheumatrexAny medication taken in excess can have serious consequences. If you suspect an overdose of Generic for Rheumatrex, seek medical attention immediately.Side Effects of Generic for RheumatrexLike other medicines, Generic for Rheumatrex can cause some side effects. If they do occur, the side effects of Generic for Rheumatrex are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.It is pertinent to note that side effects of Generic for Rheumatrex cannot be anticipated. If any side effects of Generic for Rheumatrex develop or change in intensity, the doctor should be informed as soon as possible.Generic for Rheumatrex can cause side effects such as nausea, vomiting, dizziness, headache, and blurred vision. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Generic for Rheumatrex.Drug Interaction – Cheap Prescription Drug Generic for RheumatrexUsually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Generic for Rheumatrex, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.Generic for Rheumatrex can interact with steroids and non-steroidal anti-inflammatory drugs.Also, tell your prescriber or health care professional if you are a frequent user of drinks containing caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.What drug(s) may interact with Generic for Rheumatrex?Azathioprine, Chloramphenicol, Hydroxychloroquine, Ibuprofen, Phenytoin, Prednisone, Probenecid, Tetracycline, TheophyllineIt may be noted that drugs other than those listed above may also interact with Generic for Rheumatrex.Before using Generic for Rheumatrex, ask the following questions to the doctor:Is it possible for me to take Generic for Rheumatrex with other drugs?Should certain beverages, foods and other products be avoided when I take Generic for Rheumatrex?What are the possible drug interactions of Generic for Rheumatrex?How will Generic for Rheumatrex work in my body?How should Generic for Rheumatrex be taken?How to reduce the risk of Generic for Rheumatrex drug interactions and side effects?Warnings and PrecautionsThe health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Generic for Rheumatrex is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

 

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