所属类别: 100毫克/瓶

包装规格: 100毫克/瓶




原产地英文商品名:ALIMTA 100MG SDV PWD EL 1/EA














生产厂家:Eli Lilly(礼来公司上市)




主要经尿清除。在肾功能正常的患者(肌苷清除率为90 ml/min),Alimta的系统清除率为91.8 ml/min。与顺铂、叶酸、维生素B12联合应用时不影响Alimta的药代动力学。






Alimta仅可静脉滴注,与顺铂联用,推荐剂量为500 mg/m2,第1天,滴注超过10分钟,21天为一个周期。顺铂推荐剂量为75 mg/m2,在Alimta滴注结束后30分钟开始滴注,时间超过2小时。肌苷清除率> 45 ml/min的患者不需调整剂量,肌苷清除率<45 ml/min的患者不建议使用Alimta。接受Alimta治疗的患者应同时应用叶酸和维生素B12,可减少治疗相关的血液学毒性和胃肠道毒性。任何疑问,请遵医嘱!


用于有严重培美曲唑过敏史的患者不良反应主要不良反应为骨髓抑制,表现为中性粒细胞减少症、血小板减少症和贫血。还有发热、感染、口腔炎/咽炎、皮疹/脱皮。对怀孕妇女可影响胎儿。 培美曲塞二钠项目推荐报告别差异。肝功能障碍者,升高的AST、ALT、胆红素不影响Alimta的代谢。


Medication nameGeneric name: Pemetrexed – InjectionPronunciation: (peh-meh-TREX-ed)Brand name(s): AlimtaUsesPemetrexed is used to treat certain types of cancer (e.g., lung cancer, mesothelioma). It is a chemotherapy drug that is used alone or in combination with other medications to slow or stop cancer cell growth.How to useThis medication comes with a Patient Information Leaflet available from your pharmacist. Read it carefully before you start using pemetrexed. If you have any questions regarding the information, consult your doctor or pharmacist.This medication is given by injection into a vein by a healthcare professional, usually over 10 minutes, once every 3 weeks.The dosage is based on your medical condition, body size, and response to therapy.To lower your chance of side effects, it is very important that you take folic acid vitamins and receive vitamin B12 shots before and during treatment with pemetrexed. Folic acid vitamins are available over-the-counter without a prescription, and folic acid can be found in many multivitamin products. Make sure your vitamin contains between 400 to 1000 micrograms (0.4 to 1 milligram) of folic acid. Take folic acid daily for at least 5 out of 7 days before your first dose of pemetrexed, during treatment, and for 3 weeks after your last treatment.Consult your doctor or pharmacist if you need help choosing a folic acid vitamin. Your doctor will give you a vitamin B12 shot into the muscle, usually 1 week before your first dose of pemetrexed and then once every 9 weeks during your treatment. Do not substitute oral vitamin B12 for the vitamin B12 shots. Consult your doctor or pharmacist for more details.To reduce your chance of having a skin reaction while using pemetrexed, your doctor will prescribe a corticosteroid medicine (e.g., dexamethasone) to take for a short period around the time of each treatment. Consult your doctor or pharmacist for more details.If this medication touches your skin, wash the skin immediately and completely with soap and water.PrecautionsBefore using pemetrexed, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions.Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease.Before using this medication, tell your doctor or pharmacist your medical history, especially of: decreased bone marrow function/blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia), kidney problems, liver problems.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine.Use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured.Wash your hands well to prevent the spread of infections.This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.Limit alcoholic beverages.This medication is not recommended for use during pregnancy. It may cause harm to an unborn baby. Consult your doctor for more details and to discuss reliable forms of birth control. It is recommended that men and women use two effective forms of birth control (e.g., condoms, birth control pills) while using this medication and for some period afterwards.It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.Drug interactionsDrug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs such as aspirin, ibuprofen, naproxen).Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually these dosages are 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.Side effectsNausea, vomiting, loss of appetite, constipation, diarrhea, mouth sores, headache, body aches/pains, dizziness, and tiredness may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Not eating before your treatment may help relieve vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Temporary hair loss may occur. Normal hair growth should return after treatment has ended.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fast/pounding heartbeat, change in the amount of urine, dark urine, yellowing eyes/skin, severe stomach/abdominal pain, pain/redness/swelling of arms or legs, sore throat, painful/difficult swallowing, mental/mood changes, depression, numbness or tingling of the hands/feet, easy bruising/bleeding.Get medical help right away if any of these rare but very serious side effects occur: chest pain, new or worsening shortness of breath.This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills or persistent sore throat.A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.Pemetrexed can commonly cause a rash that is usually not serious and that can be prevented by taking corticosteroid medication (see How to Use section). However, if you do develop a rash, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, get medical help right away if you develop a rash.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.Missed doseFor the best benefits, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.OverdoseIf overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.NotesLaboratory and/or medical tests (e.g., complete blood counts, kidney and liver function tests) should be performed to monitor your progress or check for side effects. Consult your doctor for more details.Medical alertYour condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).StorageNot applicable. This medication is given in a clinic and will not be stored at home.Photos by medication strengthClick the "Photos" link to see sample photographs for a specific medication strength.Common strengthsAlimta 100 mg IV SolutionAlimta 500 mg IV Solution*The photos shown are samples only. Not all photos of the drug may be displayed. Your medication may look different. If you have questions, ask your pharmacist.Important noteHOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.Information last revised March 2013. Copyright(c) 2013 First DataBank, Inc.Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First DataBank, Inc., 2012. This copyrighted material has been downloaded from a licensed data provider.The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment


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