波普瑞韦胶囊Boceprevir(Victrelis 200mg Capsules)说明书

产地国家:意大利

处方药:是

所属类别: 200毫克/胶囊 84胶囊

包装规格: 200毫克/胶囊 84胶囊

计价单位:盒

生产厂家英文名:SCHERING

原产地英文商品名:VICTRELIS 200mg/cap 84caps

原产地英文药品名:BOCEPREVIR

中文参考商品译名:VICTRELIS 200毫克/胶囊 84胶囊

中文参考药品译名:波普瑞韦

简介

部份中文波普瑞韦处方资料(仅供参考)

商品名称: Victrelis

通用名称: 波普瑞韦胶囊

英文名称: boceprevir

汉语拼音: Bopuruiweijiaonang

适 应 症

Victrelis是一种丙型肝炎病毒(HCV)NS*/4A蛋白酶抑製剂适用于与聚乙二醇干扰素α和利巴韦林【ribavirin】联用基因型*感染慢性丙型肝炎CHC)的治疗,在有代偿性肝病(≥*8岁)成年患者,包括肝硬变,波普瑞韦说明书既往未治疗或既往干扰素和利巴韦林治疗已失败患者。 VICTRELIS必须作为单药治疗使用。

用法用量

800mg每天口服三次给药(每*-*小时)与食物(一餐或小吃)。(*)VICTRELIS必须与聚乙二醇干扰素α和利巴韦林联用给药。(2)为特殊给药指导参考聚乙二醇干扰素α和利巴韦林包装插件。

不良反应

在临床试验中接受VICTRELIS与PegIntron和REBETOL联用成年受试者中最常报导的不良反应(大于**%受试者)是疲乏,波普瑞韦价格 贫血,噁心,头痛和味觉障碍。

禁 忌

(*)因为VICTRELIS必须与聚乙二醇干扰素α和利巴韦林给药,也应用对聚乙二醇干扰素α和利巴韦林所有禁忌证。(2)因为利巴韦林可能致出生缺陷和胎儿死亡,妊娠妇女中和女性伴侣妊娠男性禁忌boceprevir与聚乙二醇干扰素α和利巴韦林联用。(*)与高度依赖CYP*A4/*清除的药物共同给药,波普瑞韦规格 和因为升高血浆浓度伴随严重和/或危及生命事件。(4)强CYP*A4/*诱导剂wher显著减低boceprevir血浆浓度可能伴随减低疗效。

注意事项

Victrelis与利巴韦林和聚乙二醇干扰素α使用:(*)利巴韦林可能致出生缺陷和胎儿死亡:波普瑞韦胶囊多少钱在女性患者和男性患者的女性伴侣中避免妊娠。治疗前患者必须有妊娠检验阴性;使用两种或更多方式避孕,波普瑞韦疗程 和每月妊娠检验。(2)贫血 –Victrelis增添至聚乙二醇干扰素α和利巴韦林与单独聚乙二醇干扰素α和利巴韦林比较是伴随另外的血红蛋白浓度减低。(*)中性粒细胞减少 – Victrelis增添至聚乙二醇干扰素α和利巴韦林可能导致伴随单独聚乙二醇干扰素α和利巴韦林治疗中性粒细胞减少恶化。

贮 藏

贮存在冰箱2-8°C(*6-46°F)直至发放。避免暴露于过热。波普瑞韦哪裡卖 对使用患者,冰箱贮存Victrelis胶囊可保持稳定至标籤上失效期。 Victrelis也可贮存在室温至2*°C(**°F) *个月。保持容器密闭。

生产企业:默沙东製药

英文版说明书

Victrelis(boceprevir)What is Victrelis?Victrelis (boceprevir) is a treatment option for adults with chronic hepatitis C virus (HCV) genotype 1 infections. The US Food and Drug Administration (FDA) approved Victrelis in May 2011. It is marketed by the pharmaceutical company Merck & Co.People with HCV have a long-lasting infection that causes the liver to become inflamed. This inflammation can cause serious damage to the liver, including liver failure and liver cancer.If left untreated, the HCV virus can often lead to a liver condition called cirrhosis.Victrelis is a treatment for HCV that cannot be taken alone. The FDA approved it for use only in combination with two other HCV treatments–peginterferon alfa and ribavirin.How does Victrelis work?The HCV virus is the cause of an HCV infection. If it is not treated, the HCV virus will keep multiplying.This means there will be larger and larger amounts of the virus in the person’s body, causing more liver damage. In order to cure the infection, the virus needs to stop replicating to be eliminated from the person’s body.The active mechanism in Victrelis is boceprevir. Boceprevir is a type of drug called a “protease inhibitor.” These kinds of drugs work by interrupting the life cycle of the HCV virus, so that it cannot mature and multiply. Peginterferon alfa and ribavirin also help the body to attack the virus and prevent the virus from multiplying.Victrelis should be taken with food three times a day. The patient’s healthcare provider will advise about when and how to take the ribavirin and peginterferon alfa.To gain approval from the FDA, Victrelis was tested in studies that included more than 1,500 adults with HCV. About two-thirds of the patients who received Victrelis were considered to be cured when they were tested for the HCV virus 24 weeks after the study ended.A person with HCV is “cured” when the virus can no longer be detected in the person’s bloodstream. However, this does not mean that the virus will never return. If this happens, it is called a “relapse” of the HCV infection.For more information about the effectiveness of Victrelis, click here.Victrelis is approved for treating adults with HCV, who:•Have never been treated for HCV before, or•Have had previous treatment for HCV with peginterferon alfa and ribavirin, but the treatment did not work for themPeople with HCV who have a less advanced form of cirrhosis called “compensated cirrhosis” can also take Victrelis. However, it is not indicated for patients with more advanced cirrhosis or liver damage.One of the medicines that must be taken with Victrelis – ribavirin – can cause serious birth defects. For this reason, it is very important that women taking ribavirin should not become pregnant. A woman whose male partner is taking ribavirin should also not get pregnant.Victrelis can interact badly with

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